| 8.00 - 8.45 |
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Arrival & Registration |
| 8.45 - 9.00 |
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Welcome |
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Siddharthan Chandran - Director, UK DRI |
| 9.00 - 10.00 |
Chair: Kathryn Bowles |
Session 1: Plenary I |
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Sonia Gandhi - The Francis Crick Institute & UCL, UK |
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"Finding your way: maps, models and mechanisms" |
| 10.00 -10.30 |
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Break |
| 10.30 - 12.00 |
Chairs: Niamh O'Brien & Rachel Hodgson |
Session 2: 2D Models I |
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10.30 - 10.50: |
Wendy Noble - University of Exeter, UK |
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"Studying the dynamics of tau processing by human iPSC-astrocytes as a tool to define disease mechanisms" |
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10.50 - 11.10: |
Jackie Casey - UCL, UK |
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"Establishing iPSC models to study the role of 4R tau and P301L mutations on axonal transport" |
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11.10 - 11.30: |
Andreas Hermann - University Medical Center Rostock, Germany |
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"Neuron specific IFN type 1 signalling in (FUS-)ALS induce neurodegeneration and offers new biomarker driven individualized treatment options for (FUS-)ALS" |
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11.30 - 11.45: |
Rachel Hodgson - University of Sheffield, UK |
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"Nuclear TDP-43 condensation induced by stress and C9orf72-derived DPRs leads to TDP-43 loss of function" |
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11.45 - 12.00: |
Poster Flash Talks |
| 12.00 - 13.15 |
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Lunch & Poster Session I |
| 13.15 - 15.00 |
Chairs: Stefan Hauser & Annerieke Sierksma |
Session 3: Emerging Models & Technologies |
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13.15 - 13.35 |
Linna Zhou - University of Oxford |
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"3D Printing Neural Tissues for Disease and Repair" |
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13.35 - 13.55 |
Andrea Serio - King's, UK |
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"Shape Matters: Combining engineering, stem cell modelling and imaging to learn about neurobiology and neurodegeneration" |
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13.55 - 14.15 |
Renzo Mancuso - VIB, Belgium |
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"Xenotransplantation models to study human microglial biology in neurodegeneration" |
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14.15 - 14.30 |
Annerieke Sierksma - KU Leuven, Belgium |
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"Genetic diversity in human microglia modulates responses to amyloid pathology in Alzheimer’s disease" |
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14.30 - 15.00 |
Clotilde Lagier-Tourenne - MGH, Harvard, USA |
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"Genetic and pharmacological screens to identify new therapeutic targets in ALS and frontotemporal dementia" |
| 15.00 - 15.45 |
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Session 4: Panel Discussion |
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Advantages & limitations of iPSC for modelling neurodegenerative disease |
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| 15.45 - 17.00 |
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Poster Session II |
| 17.00 - 18.00 |
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Drinks reception |
| 18.00 - 20.00 |
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Optional: Scottish Dinner |
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| Day 2 |
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27th March 2025 |
| 8.00 - 9.00 |
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Arrival & Registration |
| 9.00 - 10.00 |
Chair: Rebecca Casterton |
Session 5: Plenary II |
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Mahmoud Maina - University of Sussex, UK & Yobe State University, Nigeria |
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"From Yobe to the Globe: The African iPSC Initiative to Elucidate the Molecular Mechanisms of Tauopathies Across Ancestries" |
| 10.00 - 10.30 |
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Break |
| 10.30 - 12.35 |
Chairs: Carles Calatayud Aristoy & Julien Klimmt |
Session 6: 3D Models I |
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10.30 -10.50: |
Carles Calatayud Aristoy - Leuven Brain Institute, Belgium |
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"Induced human striatal microcircuits capture dopamine modulation and functional defects induced by misfolded alpha-synuclein" |
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10.50 - 11.10: |
Florent Ginhoux - Gustave Roussy, France |
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"Mapping and modeling brain macrophages" |
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11.10 - 11.25: |
Julien Klimmt - LMU Munich, Germany |
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"A reproducible human brain tissue model to study physiological and disease-associated microglia phenotypes" |
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11.25 - 11.45: |
Selina Wray - UCL, UK |
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"Insights into the molecular basis of clinical heterogeneity using patient specific models of familial Alzheimer’s disease and Familial British Dementia" |
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11.45 - 12.05: |
Anna Williams - University of Edinburgh, UK |
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"Metformin, mitochondria, metabolism and human oligodendrocytes" |
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12.05 - 12.35: |
Taylor Bertucci - Neural Stem Cell Institute, USA |
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"Human iPSC vascular models to investigate APOE4 cerebrovascular contributions to Alzheimer's Disease" |
| 12.35 - 13.45 |
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Lunch & Poster Session III |
| 13.45 - 15.30 |
Chairs: Natalie Connor-Robson & Eliona Tsefou |
Session 7: 2D Models II |
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13.45 - 14.05 |
Sally Cowley - University of Oxford, UK |
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"Tau uptake, processing and secretion by human iPSC-microglia" |
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14.05 - 14.35 |
Tracy Young-Pearse - Harvard Medical School, USA |
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"Human iPSC-based experimental systems for capturing genetic risk and resilience for Alzheimer’s disease" |
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14.35 - 14.55 |
Rik van der Kant - Vrije Universitiet Amsterdam, Netherlands |
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"iPSC-models to study and target lipid metabolism in Alzheimer’s disease" |
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14.55 - 15.10 |
Eliona Tsefou - UCL, UK |
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"A novel iPSC-derived model recapitulates 4R tau expression and produces endogenous seed-competent tau" |
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15.10 - 15.30 |
Hazel Hall-Roberts - Cardiff University, UK |
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"Exploring Alzheimer's Disease Polygenic Risk Through iPSC-Derived Microglia Models" |
| 15.30 - 16.15 |
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Session 8: Panel Discussion |
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How can we translate iPSC models to drug discovery, development & therapeutic approval? |
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| 16.15 - 17.00 |
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Poster Session IV |
| 17.00 - 18.00 |
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Drinks reception |
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| Day 3 |
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28th March 2025 |
| 8.00 - 9.00 |
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Arrival & Registration |
| 9.00 - 10.00 |
Chair: Stefan Hauser |
Session 9: Plenary III |
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Sergiu Pașca - Stanford University, USA |
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"Instructions Included: Assembling Human Neural Circuits to Study Disease" |
| 10.00 -10.30 |
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Break |
| 10.30 - 12.20 |
Chair: Rebecca Casterton |
Session 10: Improving diversity in iPSC modelling |
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10.30 -11.00: |
Mubeen Goolam - University of Cape Town, South Africa |
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"Defining the roles of biochemical and physical cues in driving neural differentiation in African stem cells" |
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11.00 - 11.30: |
Bradford Casey - MJFF, USA |
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"Building Global Networks, Addressing a Global Disease" |
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11.30 - 11.50: |
Aleksander Rakovic - University of Lübeck, Germany |
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"Refining patient-derived iPSC models of X-linked dystonia-parkinsonism and genetic Parkinson's disease using genome editing
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11.50 - 12.20: |
Maneesha Inamdar - inStem, Bangalore, India |
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"Diversity in a Dish: Opportunities and Challenges in utilizing an Indian Cohort of Pluripotent Stem Cell Lines." |
| 12.20 - 13.00 |
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Session 11: Panel Discussion |
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How can we promote diversity in iPSC modelling? |
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| 13.00 - 14.00 |
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Lunch & Poster Session V |
| 14.00 - 15.45 |
Chairs: Kathryn Bowles & Alba Ortega Gascó |
Session 12: 3D Models II |
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14.00 - 14.20 |
Dries Braeken - IMEC, Belgium |
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"Nanotechnology enabling advanced in vitro human models" |
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14.20 - 14.40 |
Bhuvaneish Selvaraj - University of Edinburgh, UK |
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"Human stem cell organoid models to study cell-cell communications in neurodegenerative diseases" |
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14.40 - 15.00 |
Andras Lakatos - University of Cambridge, UK |
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"Early cell network vulnerability revealed by a human 3D organoid ALS model" |
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15.00 - 15.15 |
Alba Ortega Gascó - University of Barcelona, Spain |
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"Cortico-Hippocampal Assembloids: A Novel Tool for Studying Alzheimer's Disease" |
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15.15 - 15.45 |
Sally Temple - Neural Stem Cell Institute, USA |
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"Cortical Organoids: A Window into the Development of FTD-tau" |
| 15.45 - 16.15 |
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Poster prizes & Close |
